Exome sequencing is a capture based method developed to identify variants in the coding region of genes which affect protein function. While exome capture methods using PCR, hybrid capture and molecular inversion probes exist, the most common and efficient strategies are in-solution capture methods. In-solution capture utilizes pools of oligonucleotides or probes bound to magnetic beads, whose sequence has been designed to hybridize to exon regions. After binding to genomic DNA, these probes are pulled down and washed, allowing exon regions to be selectively sequenced.
While there are approximately 180,000 exons in the human genome, constituting less than 2% of total sequence, the exome contains ~80-90% of known disease causing variants making it a cost-effective alternative to whole genome sequencing. When performing exome-seq, users should not only consider average on-target coverage but also the local coverage of particular sites of interest. When choosing between exome and whole genome sequencing (WGS), consider that exome sequencing has the advantage that oligonucleotides are designed to particular genomic regions where typical coverage with WGS is not enough for SNP calling. It is also more affordable enabling the analysis of more individuals and populations. With WGS, you can detect variants in regions not covered by exome capture allowing or the identification of structural and non-coding variants associated with disease.
The consumption of whole exome sequencing has exceeded 120 K samples per year. Whole exome sequencing is mainly produced by American companies. Mainly largest producers in the world are located in US.
The demand of whole exome sequencing service is very strong in Chinese market, especially in Beijing, Guangzhou and Shanghai. These cities have become the fastest-growing areas, because these cities continue to improve basic health care and scientific research.

The Global Whole Exome Sequencing Market size was xxx million USD with a CAGR xx % from 2018- 2022. It will stretch to xxx million USD in 2023 with a CAGR of xx % from 2023 - 2030.

As the report focuses on global Whole Exome Sequencing Market, mainly in Europe and Asia Pacific, North America, Middle East and Africa, and South America. This report segmented the Market on the basis of regions, manufacturers, applications, and type.

in addition, this report introduces Market competition situation among the vendors and company profile, besides, Market price analysis and value chain features are covered in this report.

In Market segmentation by manufacturers, the report covers the following companies-

Illumina
Thermo Fisher
Roche
Angilent
Eurofins
Sengenics
Ambry
Macrogen
BGI
Novo Gene

In Market segmentation by geographical regions, the report has analyzed the following regions-
North America (USA, Canada and Mexico)
Europe (Germany, France, UK, Russia and Italy)
Asia-Pacific (China, Japan, Korea, India and Southeast Asia)
South America (Brazil, Argentina, Columbia etc.)
Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

In Market segmentation by types covers:

Agilent HaloPlex
Agilent SureSelect
Illumina TruSeq Exome
Roche Nimblegen SeqCap
MYcroarray MYbaits
In Market segmentation by applications :

Correlation Research of Normal Human
Mendelian Disease and Rare Syndrome Gene Discovery
The Research of Complex Diseases
Mouse Exome Sequencing

Apart from the drivers, restraints, and opportunities, the report also offers competitive landscape, including various growth strategies adopted by profiled players for establishing significant position in the industry. The segmentation included in the comprehensive report will help respectable manufacturers to set up their processing units in the regions and increase their global presence. This would also benefit the industry and increase the company\'s product portfolio.

The research provides answers to the following key questions:
• What is the estimated growth rate and Market share and size of the Whole Exome Sequencing Market for the forecast period 2023 - 2030?
• What are the driving forces in the Whole Exome Sequencing Market for the forecast period 2023 - 2030?
• Who are the prominent Market players and how have they gained a competitive edge over other competitors?
• What are the Market trends influencing the progress of the Whole Exome Sequencing industry worldwide?
• What are the major challenges and threats restricting the progress of the industry?
• What opportunities does the Market hold for the prominent Market players?
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